Twins vs. Astros Prediction, Odds, Picks - April 5

Data Skrive

Willi Castro and the Minnesota Twins will meet Jose Altuve and the Houston Astros on Saturday at Target Field, at 2:10 p.m. ET. The favored Twins have -120 moneyline odds to win against the underdog Astros, who are listed at +100. Minnesota is the run-line favorite (-1.5). The total for the matchup has been set at 7.5 runs.

Check out everything you need from a betting perspective on the Twins-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Astros Game Information & Odds

When: Saturday, April 5, 2025 at 2:10 p.m. ET
Where: Target Field in Minneapolis, Minnesota
How to watch on TV: MNNT and SCHN

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Twins -120 +100 7.5 +105 -125 -1.5 +160 -190

Twins vs. Astros Prediction

Score Prediction: Astros 7, Twins 6
Total Prediction: Over 7.5 runs
Win Probabilities: Twins 53%, Astros 47%

Twins vs. Astros Betting Insights

The Twins have been favorites in six games this season and won two (33.3%) of those contests.
Minnesota is 2-1 this season when entering a game favored by -120 or more on the moneyline.
The Twins have a 54.5% chance to win this game based on the implied probability of the moneyline.
The Astros were defeated in the one game they played as the underdog this season.
Houston has played as an underdog of +100 or more just one time this year and came away with a loss in that game.
The moneyline set for this matchup implies the Astros have a 50% chance of walking away with the win.

Twins Player Insights

Harrison Bader paces the Twins with three home runs and eight runs batted in.
Bader has collected a hit in two games in a row. During his last five outings he is hitting .250 with a double, three home runs and eight RBI.
Castro is hitting .250 to pace his team.
Castro ranks 54th in homers and 75th in RBI among all hitters in baseball.
Byron Buxton has a double, a home run and a walk while batting .190.
Buxton is on a two-game hitting streak entering this contest. In his last five games he is hitting .235 with a double, a home run, a walk and three RBI.
Ty France is hitting .227 with a double and a walk.
France takes a two-game streak with at least one hit into this one. In his last five games he is batting .222 with a double, a walk and two RBI.

Astros Player Insights

Altuve paces the Astros with one homers while posting a team-leading batting average of .391.
Among all hitters in the big leagues, Altuve ranks 54th in home runs and 183rd in RBI.
Altuve carries a six-game hitting streak into this matchup. During his last six games he is batting .391 with a home run, two walks and an RBI.
Jeremy Pena’s one home runs pace his team.
Among all major league hitters, Pena is 54th in homers and 183rd in RBI.
Isaac Paredes is hitting .150 with a double and five walks.
Yordan Alvarez has driven in a team-best four runs batted in.

Check out the top moments between the Baltimore Orioles and the Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.