Knicks vs. Cavaliers prediction, odds, line, spread, time: 2025 NBA picks, April 2 best bets from proven model

Imagn Images

The Tuesday NBA schedule features a high-profile Eastern Conference matchup between the Cleveland Cavaliers and New York Knicks. Cleveland is 60-15 overall and 32-5 at home, while New York is 48-27 overall and 22-15 on the road. The Knicks are looking to stay hot and win their fourth straight game after they defeated the Philadelphia 76ers 105-91 on Tuesday. The Cavs, who have the best record in the Eastern, have won four of their last five after beating the Los Angeles Clippers 127-122 on Sunday. Karl-Anthony Towns (knee) is probable, while Jalen Brunson (ankle) and Mitchell Robinson (ankle) are out for New York.

Tipoff from Rocket Arena in Cleveland is set for 7 p.m. ET. The Cavs are 10.5-point favorites in the latest Knicks vs. Cavaliers odds from SportsLine consensus, while the over/under for total points scored is 230.5. The Cavs are at -495 on the money line (risk $495 to win $100), while New York is at +375 (risk $100 to win $375). Before making any Knicks vs. Cavs picks, be sure to check out the NBA predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 24 of the 2024-25 NBA season on a sizzling 155-115 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It’s also an outstanding 21-10 (68%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has set its sights on Knicks vs. Cavaliers and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA betting lines for the game:

Knicks vs. Cavaliers spread: Cleveland -10.5
Knicks vs. Cavaliers over/under: 230.5 points
Knicks vs. Cavaliers money line: New York +375, Cleveland -495
Knicks vs. Cavaliers picks: See picks at SportsLine
Knicks vs. Cavaliers streaming: FuboTV (Try for free)

Why the Cavaliers can cover

The Cavs have legitimate championship aspirations this season. Cleveland currently holds a 4-game lead over the Boston Celtics for the top spot in the Eastern Conference playoff picture. The Cavs have also performed well versus the number this season, going 44-30-1 against the spread.

The Cavs are paced by the dynamic backcourt duo of Donovan Mitchell and Darius Garland. Mitchell averages a team-high 24.0 points per game to go with 4.9 assists and 4.5 rebounds. Garland is averaging 20.6 points and 6.7 assists per game. Big men Evan Mobley (18.6 points, 9.3 rebounds) and Jarrett Allen (13.8 points, 10.0 rebounds) are both double-double machines for Cleveland. See which team to back at SportsLine.

Why the Knicks can cover

The Knicks are one of the hottest teams in the Eastern Conference, and look to be headed towards locking up the No. 3 seed in in playoff bracket. New York has won three straight games, and five of its last six. The Knicks are also 5-1 against the spread in their last six games.

New York will get a major boost if forward Karl-Anthony Towns returns to action on Wednesday. In his first year with the Knicks, Towns is averaging 24.3 points, 12.8 rebounds, and 3.1 assists per game. Shooting guard Josh Hart continues to play at a high level for New York, with per game averages of 13.8 points, 9.6 rebounds, and 5.8 assists. See which team to back at SportsLine.

How to make Cavs vs. Knicks picks

SportsLine’s model has simulated Knicks vs. Cavs 10,000 times and is leaning Under on the total, projecting 228 combined points. The model also says one side of the spread hits in well over 50% of computer simulations. You can head to SportsLine now to see the model’s NBA picks.

So who wins Cavaliers vs. Knicks on Wednesday, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Knicks vs. Cavaliers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.