The ninth-seeded Creighton Bluejays take on the eighth-seeded Louisville Cardinals in a South Regional first-round matchup in the 2025 NCAA Tournament on Thursday afternoon. The Bluejays (24-10), who finished second in the Big East at 15-5, finished the regular season by winning 15 of their final 18 games. The Cardinals (27-7), who tied with Clemson for second in the ACC at 18-2, have won 11 of 12 and 21 of 23.

Tipoff from Rupp Arena in Lexington, Ky., is set for 12:15 p.m. ET. Creighton holds a 2-1 edge in the all-time series between the teams. Louisville is a 2.5-point favorite in the latest Creighton vs. Louisville odds from SportsLine consensus, while the over/under for total points scored is 145.5.

Before making any Creighton vs. Louisville picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Creighton vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in nearly 70% of simulations!

So who wins Creighton vs. Louisville, and which side of the spread cashes in nearly 70% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!