Astros vs. Padres Prediction, Odds, Picks - April 19

Data Skrive

The San Diego Padres and Fernando Tatis Jr. hit the field in the first game of a three-game series against Yordan Ruben Alvarez and the Houston Astros, on Saturday at Daikin Park. The Astros are -165 moneyline favorites for this matchup with the Padres (+139). Houston is the favorite on the run line (-1.5 with +127 odds). A 9-run over/under is listed for the matchup.

Here is everything you need from a betting perspective on the Astros-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Padres Game Information & Odds

When: Saturday, April 19, 2025 at 7:10 p.m. ET
Where: Daikin Park in Houston, Texas
How to watch on TV: Fox Sports 1, SCHN, and SDPA

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Astros -165 +139 9 +101 -121 -1.5 +127 -150

Astros vs. Padres Prediction

Score Prediction: Padres 4, Astros 3
Total Prediction: Under 9 runs
Win Probabilities: Astros 55%, Padres 45%

Astros vs. Padres Betting Insights

The Astros have been favorites in 11 games this season and won five (45.5%) of those contests.
Houston has played as favorites of -165 or more twice this season and lost both games.
The Astros have a 62.3% chance to win this game based on the implied probability of the moneyline.
The Padres have won in four of the seven contests they have been named as odds-on underdogs this year.
Oddsmakers have given San Diego the worst odds of winning it has seen this season with a +139 moneyline listed for this contest.
Bookmakers have implied with the moneyline set for this matchup that the Padres have a 41.8% chance of pulling out a win.

Astros Recent Betting Performance

The Astros have a 3-3 record from the six games they were moneyline favorites over their last 10 matchups.
Over their last 10 outings (all had set totals), the Astros combined with their opponents to hit the over on the run total five times.
The Astros have a 6-4-0 record against the spread over their past 10 games.

Astros Recent Stats

Stat Avg/Total Record 5-5 Runs Per Game 4.8 HR 9 ERA 3.99 K/9 9.4

Astros Player Insights

Jose Carlos Altuve has put up a team-high batting average of .311, while pacing the Astros in home runs (three).
Including all MLB batters, Altuve is 24th in batting average, 64th in on-base percentage, and 67th in slugging.
Altuve carries a two-game hitting streak into this matchup. During his last five outings he is batting .167 with a double and an RBI.
Jeremy Pena has hit three home runs to pace his team.
Pena is 57th in homers and 128th in RBI in the bigs.
Pena has eight straight games with at least one hit. During his last 10 outings he is batting .237 with two doubles, a home run, four walks and five RBI.
Isaac Paredes paces the Astros in home runs (three) and runs batted in (10).
Alvarez’s 10 runs batted in are a team-high mark.

Padres Recent Betting Performance

The Padres have played as underdogs in three of their past 10 games and have gone 2-1 in those contests.
When it comes to hitting the over, the Padres and their opponents are 5-5-0 in their last 10 games with a total.
The Padres have eight wins against the spread in their last 10 chances.

Padres Recent Stats

Stat Avg/Total Record 8-2 Runs Per Game 5 HR 12 ERA 2.80 K/9 8.3

Padres Player Insights

Tatis paces the Padres with six home runs and 14 runs batted in, while recording a team-high batting average of .348.
In all of the big leagues, Tatis ranks fourth in homers and 19th in RBI.
Tatis takes a hitting streak of six games into this game. In his last 10 outings he is batting .282 with five home runs, six walks and nine RBI.
Manny Machado has eight doubles, two home runs and eight walks while hitting .324.
Among all major league hitters, Machado is 100th in homers and 84th in RBI.
Luis Sangel (Reveron) Arraez has three doubles, two home runs and three walks while batting .275.
Xander Bogaerts is hitting .258 with six doubles and 10 walks.