Astros vs. Angels Prediction, Odds, Picks - April 12

Data Skrive

The Houston Astros and Los Angeles Angels will play on Saturday at Daikin Park, at 7:10 p.m. ET, with Jose Altuve and Taylor Ward among those expected to step up at the plate. The Astros have been listed as -141 moneyline favorites for this matchup against the Angels (+119). Houston is the favorite on the run line (-1.5). The total is 8.5 runs for this game (with -122 odds to hit the over and +101 odds to go under).

Here’s everything you need to know from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Angels Game Information & Odds

When: Saturday, April 12, 2025 at 7:10 p.m. ET
Where: Daikin Park in Houston, Texas
How to watch on TV: SCHN and FDSSC

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Astros -141 +119 8.5 -122 +101 -1.5 +148 -178

Astros vs. Angels Prediction

Score Prediction: Astros 5, Angels 4
Total Prediction: Over 8.5 runs
Win Probabilities: Astros 52%, Angels 48%

Astros vs. Angels Betting Insights

The Astros have been favorites in six games this season and won two (33.3%) of those contests.
Houston has played as favorites of -141 or more twice this season and lost both games.
The bookmakers’ moneyline implies a 58.5% chance of a victory for the Astros.
The Angels have been chosen as underdogs in nine games this year and have walked away with the win six times (66.7%) in those games.
This season, Los Angeles has been victorious three times in five chances when named as an underdog of at least +119 or longer on the moneyline.
The moneyline set for this matchup implies the Angels have a 45.7% chance of walking away with the win.

Astros Player Insights

Altuve paces the Astros with three home runs while racking up a team-high batting average of .346.
Of all hitters in MLB, Altuve ranks 28th in homers and 80th in RBI.
Altuve has collected a hit in five games in a row. In his last five games he is hitting .375 with two home runs, two walks and five RBI.
Jeremy Pena is batting .186 with a double, two home runs and four walks.
Pena is 56th in home runs and 238th in RBI in the majors.
Pena heads into this game looking for his third game in a row with a hit. During his last five outings he is batting .250 with a double and two walks.
Yordan Alvarez has driven in a team-best eight runs batted in.
Alvarez has at least one base hit in two straight games. In his last five games he is batting .294 with a home run, five walks and four RBI.
Jake Meyers is batting .276 with two doubles and four walks.
Meyers has recorded at least one hit in five games in a row. During his last five outings he is batting .316 with two doubles, four walks and an RBI.

Angels Player Insights

Kyren Paris paces the Angels with five home runs.
Among all hitters in MLB, Paris’ home run total ranks fourth and his RBI tally ranks 41st.
Mike Trout been a consistent power bat this season, as he paces his team with five home runs and 11 runs batted in.
Trout ranks fourth among all hitters in the big leagues in homers, and 16th in RBI.
Logan O’Hoppe has racked up a team-high batting average of .359, and leads the Angels in home runs (five).
Ward is hitting .235 with a double, three home runs and three walks.